Factors that Increase the Likelihood of Ovarian Endometriosis Relapsing after Surgical Excision: A Systematic Review and Meta-Analysis

Background: Determine potential triggers for ovarian endometriosis recurrence to provide individualized long-term management and follow-up improved patient outcomes. Methods: Relevant data were acquired through systematic retrieval from PubMed, Embase, Web of Science, Cochrane Library before October 2022. We determined the odd ratio or mean difference with their corresponding 95% confidence interval (CI) explore relationship between relevant risk factors postoperative relapse. Results: This meta-analysis ultimately covered 6388 patients 18 trials, findings demonstrated that was associated age at surgery [mean (MD) (95% CI) = –0.69 (–1.33~–0.05), p 0.04], family history [odds (OR) 2.18 (1.10~4.29), 0.02], preoperative carbohydrate antigen (CA-125) [MD 24.08 (–7.55~40.61), 0.004], laterality (EMs) [OR 1.19 (1.00~1.40), presence adenomyosis 1.53 (1.11~2.11), 0.009], myoma 1.44 (1.07~1.94), previous endometriosis-related 1.90 (1.45~2.51), < 0.00001], r-American Fertility Society (r-AFS) stage 0.30 (0.19~0.46), 0.00001]/[OR 0.57 (0.48~0.66), 0.00001]. In addition, pregnancy 0.40 (0.19~0.82), 0.01] medication 1.64 (1.02~2.62), 0.04] indicated protective prevention Conclusions: Risk included surgery, history, CA-125, EMs, adenomyosis, myoma, r-AFS stage. preventing medication. However, menarche, infertility, extent cyst size, body mass index, dysmenorrhea unrelated recurrence. The sample size could be increased further investigations.